Abstract

Review Article

Type 2 diabetes and cancer

Snobia Munir* and Samreen Riaz

Published: 28 February, 2020 | Volume 4 - Issue 1 | Pages: 001-006

Diabetes mellitus increases the possibility of different cancers. Scientists have substantiated the link of diabetes with increased prevalence, augmented progression and improved cancer aggression. Research has strengthened link of diabetes with the colorectal cancer risk among various cancers. Diagnosis and treatment have made some progress in recent years, but Colorectal is major issue for the health of people even today. In order to reduce cancer mortality, there is importance of prophylaxis, evaluation and proper treatment. Factors distressing cancer prognosis is required by policy-making system for beneficial approaches of cancer patients and improvement of disease. Eventually diabetes- specific strategies for different cancers are explored.

Read Full Article HTML DOI: 10.29328/journal.acem.1001012 Cite this Article Read Full Article PDF

Keywords:

Diabetes; Cancer mortality; Risk; Hyperinsulinemia; Metformin

References

  1. Khaw KT, Wareham N, Bingham S, Luben R, Welch A, et al. Preliminary communication: glycated hemoglobin, diabetes, and incident colorectal cancer in men and women: a prospective analysis from the European prospective investigation into cancer-Norfolk study. Cancer Epidemiol Biomarkers Prev. 2004; 13: 915-919. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15184246
  2. Coughlin SS, Calle EE, Teras LR, Petrelli J, Thun MJ. Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults. Am J Epidemiol. 2004; 159: 1160-1167. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15191933
  3. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, et al. Cancer statistics. CA Cancer J Clin. 2005; 55: 10-30.
  4. Butt A, Riaz S. Study of protein profiling of human urine in diabetic hypertensive nephropathy versus normal healthy controls. Diabetes Technol Ther. 2010; 12: 379-386. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20388048
  5. Zhi-Jie Z, Haidong K, Yiqing S, Wei C, Genming Z, et al. Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes: a meta-analysis. Diabetes care. 2011; 34: 2323-2328. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/21949223
  6. Schulze MB, Hu FB. Primary prevention of diabetes: what can be done and how much can be prevented? Annu Rev Public Health. 2005; 26: 445-467. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15760297
  7. Larsson SC, Giovannucci E, Wolk A. Diabetes and colorectal cancer incidence in the cohort of Swedish men. Diabetes Care. 2005; 28: 1805-1807. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15983343
  8. Gong YW, Benjuan YL, Weijuan. Type 2 diabetes mellitus and risk of oral cancer and precancerous lesions: A meta-analysis of observational studies. Oral Oncol. 2015. 51. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25650271
  9. Mills KT, Bellows CF, Hoffman AE, Kelly TN, Gagliardi G. Diabetes Mellitus and Colorectal Cancer Prognosis: A Meta-analysis. Dis Colon Rectum. 2013; 56: 1304-1319. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24105007
  10. Zhu B, Wu X, Wu B, Pei D, Zhang L, et al. The relationship between diabetes and colorectal cancer prognosis: a meta-analysis based on the cohort studies. PloS one. 2017; 12. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28423026
  11. Yasemin S. Diabetes May Increase Risk for Cancer, Especially for Women. 2018.
  12. Aura DHM, Sergio PA, Fernando LL, Manuel DG, María AGM, et al. Type 2 Diabetes in Neuroendocrine Tumors: Are Biguanides and Statins Part of the Solution? J Clin Endocrinol Metab. 2018; 1: 57-73. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30265346
  13. Guraya SY. Association of type 2 diabetes mellitus and the risk of colorectal cancer: A meta-analysis and systematic review. World J Gastroenterol. 2015; 21: 6026. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26019469
  14. Kathleen K. The Cancer-Diabetes Connection. 2018.
  15. Barbara AMara. Diabetes mellitus and cancer risk: A multisite case-control study. J Chronic Dis. 1985; 435-441. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/3998058
  16. Lecarpentier Y, Claes V, Vallée A, Hébert J. Interactions between PPAR Gamma and the Canonical Wnt/Beta-Catenin Pathway in Type 2 Diabetes and Colon Cancer. PPAR research. 2017. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28298922
  17. Larsson SC, Orsini N, Wolk A. Diabetes mellitus and risk of colorectal cancer: a meta-analysis. J Natl Cancer Inst. 2005; 97: 1679-1687-1987. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16288121
  18. Vernieri C, Galli F, Laura F, Sara L. Impact of Metformin Use and Diabetic Status during Adjuvant Fluoropyrimidine‐Oxaliplatin Chemotherapy on the Outcome of Patients with Resected Colon Cancer: A TOSCA Study Subanalysis. The oncologist. 2019; 2018: 0442. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/30606884
  19. Fransgaard T, Thygesen LC, Gögenur I. Metformin increases overall survival in patients with diabetes undergoing surgery for colorectal cancer. Ann Surg Oncol. 2016; 23: 1569-1575. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26714936

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