Abstract

Case Report

Overlap of two unusual condition in childhood: hibernoma and central diabetes insipidus

Kübra ARSLAN*, Ayça TÖREL ERGÜR and Mehmet Ali YİNANÇ

Published: 07 March, 2022 | Volume 6 - Issue 1 | Pages: 001-003

Central Diabetes Insipidus (CDI) results from the inability to secrete ADH secreted by the neurohypophysis system to control water-electrolyte metabolism. In the etiology of CDI in childhood, many congenital and acquired central nervous system (CNS) tumors (germinoma, pinealoma, craniopharyngioma, optic glioma, acute myeloid leukemia), infiltrative diseases (Langerhans cell histiocytosis, sarcoidosis), infections (meningitis, tuberculosis, encephalitis), autoimmune events, head trauma, idiopathic) can be responsible [1]. Hibernomas, which are very rare in childhood, may also rarely involve the central nervous system.

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References

  1. Di Lorgi N, Napoli F, Allegri AEM, Olivieri I, Bertelli E, et al. Diabetes Insipidus – diagnosis and management. Horm Res Paediatr. 2012; 77: 69–84. PubMed: https://pubmed.ncbi.nlm.nih.gov/22433947/
  2. Mermer M, Acar Tek N. Adipose tissue and its effects on energy metabolism. Süleyman Demirel University J Health Sci. 2017; 40-46.
  3. Van Marken Lichtenbelt WD, Vanhommerig JM, Smulders NM, Drossaerts JMAFL, Kemerink GJ, et al. Cold-activated Brown adipose tissue in healty men. N Engl J Med. 2009; 360: 1500-1508. PubMed: https://pubmed.ncbi.nlm.nih.gov/19357405/
  4. Trujillo O, Cui IH, Malone M, Suurna M. An unusual presentation of a rare benign tumor in head and neck: a review of hibernomas. Laryngoscope. 2015; 125: 1656-1659. PubMed: https://pubmed.ncbi.nlm.nih.gov/25583551/
  5. Guidry CA, McGahren ED, Rodgers BM, Kane BJ. Pediatric cervicomediastinal hibernoma: A case report. J Ped Surg.2013; 48: 258-261. PubMed: https://pubmed.ncbi.nlm.nih.gov/23331827/
  6. Evers LH, Gebhard M, Lange T, Siemers F, Mailänder P. Hibernoma – Case Report and Literature Review. Am J Dermatopathol. 2009; 31: 685-686. PubMed: https://pubmed.ncbi.nlm.nih.gov/19668076/
  7. Honoki K, Morita K, Kasai T, Fujii H, Kido A, et al. Hibernoma of the axillary region: a rare benign adipocytic tumor. Rare Tumors. 2010; 2: 20-21. PubMed: https://pubmed.ncbi.nlm.nih.gov/21139952/
  8. Ahmed SA, Schuller I. Pediatric Hibernoma: A Case Report. J Pediatr Hematol Oncol. 2008; 30: 900-901.
  9. DeRosa DC, Lim RB, Lin-Hurtubise K, Johnson EA. Symptomatic hibernoma: a rare soft tissue tumor. Hawaii J Med Public Health. 2012; 71: 342-345. PubMed: https://pubmed.ncbi.nlm.nih.gov/23251871/
  10. Fujiwara TM, Bichet DG. Molecular biology of hereditary diabetes insipidus. J Am Soc Nephrol. 2005; 16: 2836–2846. PubMed: https://pubmed.ncbi.nlm.nih.gov/16093448/
  11. Patti G, Ibba A, Morana G, Napoli F, Fava D, et al. Central diabetes insipidus in children: Diagnosis and management. Best Pract Res Clin Endocrinol Metab. 2020; 34: 101440. PubMed: https://pubmed.ncbi.nlm.nih.gov/32646670/
  12. Rigoli L, Aloi C, Salina A, Di Bella C, Salzano G, et al. Wolfram syndrome 1 in the Italian population: genotype–phenotype correlations. Pediatr Res. 2020; 87: 456-462. PubMed: https://pubmed.ncbi.nlm.nih.gov/31266054/
  13. Little BP, Fintelmann FJ, Mino-Kenudson M, Lanuti M, Shepard JO, et al. Intrathoracic Hibernoma. A case with multimodality imaging correlation. J Thorac Imaging. 2011; 26: W20-22. PubMed: https://pubmed.ncbi.nlm.nih.gov/20871421/
  14. Mugel T, Ghoussain MA, Guinet C. MR and CT Findings in a case of hibernoma of the thigh extending into the pelvis. Eur Radiol. 1998; 8: 476-478.
  15. Ghirardello S, Garre ML, Rossi A, Maghnie M. The diagnosis of children with central diabetes insipidus. J Pediatr Endocrinol Metab. 2007; 20: 359–375. PubMed: https://pubmed.ncbi.nlm.nih.gov/17451074/
  16. Ghirardello S, Malattia C, Scagnelli P, Maghnie M. Current perspective on the pathogenesis of central diabetes insipidus. J Pediatr Endocrinol Metab. 2005; 8: 631-645. PubMed: https://pubmed.ncbi.nlm.nih.gov/16128239/ 

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