Abstract

Letter to Editor

Myxedema coma in COVID-19

Yuichi Takashi* and Daiji Kawanami*

Published: 31 July, 2021 | Volume 5 - Issue 1 | Pages: 029-030

SARS-CoV-2 infection is associated with thyroid disorders. It has been reported that myxedema coma (MC) can be complicated with COVID-19. COVID-19-related thyroid disorders consist of a broad spectrum of thyroid dysfunction, from thyrotoxicosis to decompensated hypothyroidism. It is possible that both primary and central thyroid disorders are induced by COVID-19 due to systemic inflammatory and immune responses. We experienced two cases in which patients with COVID-19 developed MC with central hypothyroidism. It is likely that MC affected the severity of COVID-19. It is necessary to consider the existence of MC during SARS-CoV-2 infection. We propose the potential mechanisms.

Read Full Article HTML DOI: 10.29328/journal.acem.1001021 Cite this Article Read Full Article PDF

Keywords:

Myxedema; Coma; SARS-CoV-2; COVID-19; Cytokine release syndrome

References

  1. Sinha P, Calfee CS, Cherian S, Brealey D, Cutler S, et al. Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study. Lancet Respir Med. 2020; 8: 1209-1218. PubMed: https://pubmed.ncbi.nlm.nih.gov/32861275/
  2. Ono Y, Ono S, Yasunaga H, Matsui H, Fushimi K, et al. Clinical characteristics and outcomes of myxedema coma: Analysis of a national inpatient database in Japan. J Epidemiol. 2017; 27: 117-22. PubMed: https://pubmed.ncbi.nlm.nih.gov/28142035/
  3. Mathew V, Misgar RA, Ghosh S, Mukhopadhyay P, Roychowdhury P, et al. Myxedema coma: a new look into an old crisis. J Thyroid Res. 2011; 2011: 493462. PubMed: https://pubmed.ncbi.nlm.nih.gov/21941682/
  4. Dixit NM, Truong KP, Rabadia SV, Li D, Srivastava PK, et al. Sudden Cardiac Arrest in a Patient With Myxedema Coma and COVID-19. J Endocr Soc. 2020; 4: bvaa130. PubMed: https://pubmed.ncbi.nlm.nih.gov/32984743/
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