Abstract

Mini Review

Could metabolic risk factors contribute to the development of cervical cancer?

Maydelín Frontela-Noda*, Eduardo Cabrera-Rode, Maite Hernández-Menéndez and Raquel Duran-Bornot

Published: 18 December, 2019 | Volume 3 - Issue 1 | Pages: 001-006

The role of human papillomavirus infection as etiological factor for cervical squamous intraepithelial lesions and cervical cancer is well established. However, the presence of this virus is not sufficient condition for developing of cervical cancer. Currently, the contribution of other viral, environmental and host cofactors in triggering of this neoplasm is being investigated. Some metabolic risk factors have been associated with the development of several gynecological cancers such as endometrium, ovary and cervix. However, the mechanisms through which these factors contribute to carcinogenesis are complex and not fully elucidated. Few interventions regarding host metabolic factors have been performed on women at risk of developing cervical cancer. Some specific treatments and or changes in lifestyles could be carried out to avoid or delay progression to this kind of cancer. This paper aims to enlarge and update this topic based on the article ¨Association between components of the metabolic syndrome and degree of cervical squamous intraepithelial lesions in Cuban women¨, with emphasis on possible mechanisms that explain the link between central adiposity, insulin resistance and dyslipidemia with risk of premalignant lesions and cervical cancer. 

Read Full Article HTML DOI: 10.29328/journal.acem.1001011 Cite this Article Read Full Article PDF

Keywords:

Cervical squamous intraepithelial lesions (SIL); Cervical cancer (CxCa); Metabolic risk factors; Central adiposity; Insulin resistance; Dyslipidemia

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